Thursday, May 20, 2021

Will ADE mean adieu to COVID19-vaccines?

 Reminder! An updated version of this article is available here https://bit.ly/Antibody-Dependent-Enhancement

Ade is a version of the French friendly farewell  adieu but ADE is the acronym for the rather unfriendly  Antibody-Dependent Enhancement(ADE) and it's not a conspiracy theory.  Alas.

 It's an uncanny machanism of the immune system, which basically  means that  disease due to infection after vaccination is worse than disease caused by infection without prior vaccination, for some patients.  If the second infection is with a different variant of the virus than the variant/ wild-type  the vaccine is based on.

ADE was first discovered with dengue virus infections.

A reinfection with dengue virus makes the clinical symptoms worse and heightens the risk of devoloping severe dengue fever. So ADE is a immunological phenomenon which can even happen without vaccinations.  

ADE in dengue infections

So the mRNA B-cell vaccine attack on the Mighty Corona may go either way. 

The game is still undecided.

 DON'T BELIEVE IN POLITICS. 

ACCEPT BIOLOGICAL REALITY.

"...two different ADE risks have possible implications for SARS-CoV-2 B-cell vaccines for subsets of populations based on age, cross-reactive antibodies, variabilities in antibody levels over time, and pregnancy. These models place increased emphasis on the importance of developing safe SARS-CoV-2 T-cell vaccines that are not dependent upon antibodies."¹

1)Ricke DO. Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies. Front Immunol. 2021 Feb 24;12:640093. doi: 10.3389/fimmu.2021.640093. PMID: 33717193; PMCID: PMC7943455.

Click below to read the paper:

Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies.

In a paper published October 28 2020 in the International Journal of Clinical Practice the authors came to this sobering conclusion:

"Based on the published literature, it should have been obvious to any skilled medical practitioner in 2019 that there is a significant risk to vaccine research subjects that they may experience severe disease once vaccinated, while they might only have experienced a mild, self-limited disease if not vaccinated"²

Back then this concerned only vaccine research subjects, but nowadays this pertains to all vaccinees.

2) Cardozo T, Veazey R. Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease. Int J Clin Pract. 2021 Mar;75(3):e13795. doi: 10.1111/ijcp.13795. Epub 2020 Dec 4. PMID: 33113270; PMCID: PMC7645850.

Here is the link to the paper:

Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease.


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